Insulin Resistance: A Getting route to Metabolic Dysfunction and Cancer: A review

Abstract

The impaired reaction of insulin target organs to normal insulin concentrations is known as insulin resistance. One of the main pathologic characteristics of several metabolic illnesses, including type 2 diabetes mellitus, is the process. What causes insulin resistance specifically? No one actually knows, but many valid explanations have been put out. In addition to summarizing the function of insulin in glucose metabolism in the traditional metabolic organs, this review will list the mechanisms (inflammatory response, end-of-retinoid stress, ectopic lipids in the liver, and skeletal muscle) that have been proposed to explain insulin resistance. The other one makes suggestions for possible treatment approaches for the inflammation linked to insulin resistance. The other suggests that medicine may be used to treat any insulin resistance. the failure of adipose tissue to store energy may be the primary cause of insulin resistance. Since there is currently no gold standard test for insulin resistance, it is challenging to define the condition clinically. However, the metabolic effects of insulin resistance, as outlined by the metabolic syndrome and insulin resistance syndrome, are a clinical sign of insulin resistance. Gaining a better understanding of the effects of insulin resistance and the syndromes that arise from it is the aim of this work. Insulin resistance, which can lead to cancer and a host of other hormone-related problems, is caused by DNA damage.